Chemical Mixture Calculator - A novel tool for mixture risk assessment

Risk assessment of environmental mixture effects

In the environment, organisms are exposed to a diverse array of chemicals in complexmixtures. Themajority of approaches that aim to assess the risk of environmental chemical mixtures, including those used by regulatory bodies, use toxicity data generated from the individual component chemicals to predict the overall mixture toxicity. It is assumed that the behaviour of chemicals in a mixture ca...

Screening for a Multivariate Mixture Normal Distribution

MAIES: A Tool for DNA Mixture Analysis

We describe an expert system, Maies, under development for analysing forensic identification problems involving DNA mixture traces using quantitative peak area information. Peak area information is represented by conditional Gaussian distributions, and inference based on exact junction tree propagation ascertains whether individuals, whose profiles have been measured, have contributed to the mi...

Reproductive toxicology. Chemical mixture.

After whole-genome duplication (WGD), deletions return most loci to single copy. However, duplicate loci may survive through selection for increased dosage. Here, we show how the WGD increased copy number of some glycolytic genes could have conferred an almost immediate selective advantage to an ancestor of Saccharomyces cerevisiae, providing a rationale for the success of the WGD. We propose t...

Reproductive toxicology. Chemical mixture.

Background: Intestinal failure is the outcome of a number of gastrointestinal diseases and characterized by significant reduction in functional gut mass. If not resolved patients often face longterm nutritional support. This study gathered information about how patients referred with intestinal failure are managed in specialised European centres. Methods: A questionnaire was circulated in 7 Eur...